Tablet Granulation

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Brief discussion on tablet granulation process
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  Anup Bajracharya, QA Officer,,Quest  Tablet Granulation  Anup Bajracharya, QA Officer,,Quest Introduction ãGranulation is the process in which primary powder particles are made toadhere to form larger, multi particleentities called granules .ãPharmaceutical granules typically have asize range between 0.2 and 4.0 mm.ãGranules are used in the production oftablets or capsules.ãGranules in such cases are made as anintermediate product and have a typicalsize range between 0.2 and 0.5 mm.  Anup Bajracharya, QA Officer,,Quest Reasons for Granulation ã To prevent segregation of the constituents of the powder mix.  –Segregation (or demixing) is due primarily todifferences in the size or density of thecomponents of the mix. –The smaller and/or denser particlesconcentrating at the base of a container –The larger and/or less dense ones above them. –An ideal granulation will contain all theconstituents of the mix in the correct proportionin each granule and segregation of theingredients will not occur  Anup Bajracharya, QA Officer,,Quest Granulation preventsegregation
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