BioMicroLab_VolCheck100_Overview_2015

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1. BioMicroLab Laboratory Automation for Sample Management 2. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA For…
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  • 1. BioMicroLab Laboratory Automation for Sample Management
  • 2. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA For pharmaceutical, biotech, agricultural and research laboratories that require flexible systems for growing laboratories, BioMicroLab offers modular systems to accelerate sample management workflows. BioMicroLab Product Line
  • 3. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA BioMicroLab Product Line Tube & Vial Handlers Lab Tools & Software Standalone Volume Detection Barcode Scanners Label Printers & Applicators • VolumeCheck 50 • VolumeCheck 100 • VolumeCheck 384 • XL20 (20 rack capacity) • XL9 (9 rack capacity) Benchtop Tube & Vial Handlers • XL200 (30 rack capacity) • XL100 (20 rack capacity) SampleScan line includes: • High-Speed Scanners • Frozen Rack Scanners • Single Tube Readers • Rack ID scanners • Standalone or • Integrated with a tube handler • Capper / Decapper • 5-Place Balance • Ionizer • Rack Thawing Station • And more
  • 4. 925-689-1200 | sales@biomicrolab.com | www.biomicrolab.com VolumeCheck Standalone Volume Detection 96 & 384 Well Labware Models VolumeCheck 100 VolumeCheck 384 Available Soon!
  • 5. 925-689-1200 | sales@biomicrolab.com | www.biomicrolab.com 96 Well Labware VolumeCheck100 VolumeCheck100 Standalone Volume Detection for 96 well labware
  • 6. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA Technology Overview VolumeCheck100
  • 7. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA • General purpose volume inspection system • Utilizes one non-contact sensor • Output data is the distance measured from sensor to sample level Measures the distance between the sensor and the sample meniscus with a non-contact sensor. For Example: 15mm = 350µL VolumeCheck Technology Overview
  • 8. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA Typical Applications  Production monitoring system to monitor and validate  Quality control system for liquid handling operations  Compound or sample library volume/inventory management tool Typical Customers  Reagent manufacturers  RNA / DNA synthesis  Compound sample laboratories  Biobanks or biorepositories  Molecular diagnostics VolumeCheck Applications
  • 9. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA Molecular Diagnostics  Focused on molecular and clinical diagnostic with therapeutic assays or genotyping services  Currently: Sample receipt process is usually manual via pipette, visual inspection, weighing, or liquid handler conductive tips to confirm sample volume.  All of these are time consuming and sometimes less reliable. • Application: VolumeCheck offers automated method to confirm incoming sample volume VolumeCheck Typical Customer End Users Genomic Health, Complete Genomics, Transnetyx
  • 10. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA Genomic BioBanks • Biorepository Sample Libraries  Orders for samples placed by research scientists  VolumeCheck confirms enough sample available  Samples cherry picked with liquid handler  VolumeCheck reconfirms sample volume dispensed • Result:  Up-to-date database of sample volume.  Quality control for sample volume on a well–by–well basis VolumeCheck Core Facility Applications
  • 11. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA VolumeCheck BioBank Workflow Application Researcher Sends Request for Samples LIMS Database Sample/Compound Store Sample Store Consumables 2D barcoded tubes or well plates Volume Verification Verify sample volumes Liquid Handling Assay Screening Creates assay plates
  • 12. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA • One non-contact sensor • Detects volume in uncapped well plates and tube racks • Works with water, alcohol, DMSO, TE, buffer, and other common laboratory solutions • Compatible racks: 96, 48, 24, 12 well formats Two Models for 96 labware  VolumeCheck100 • 1 minute per rack  VolumeCheck 50 • 3 minutes per rack VolumeCheck100 Features
  • 13. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA SBS standard size labware:  96 well  48 well  24 well  12 well • Plates and racks need to be greater than 41mm in height  Optional rack adapters available • Must be uncapped or uncovered VolumeCheck100 Labware Compatibility 384 well labware VolumeCheck384 model is also compatible with 384 well racks
  • 14. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA VolumeCheck system resolution may be influenced by: • Differences in labware such as conical, v-shaped, or flat-bottom well plates and tubes (see next slide) • Droplets on the wall of a tube or well • Air bubbles in sample • Plate-to-plate dimensional variations • The curve should closely represent the concentration of samples. VolumeCheck100 Accuracy Accuracy is dependent on labware and lab processes when using the system. System resolution can be maximized by: • Centrifuging sample plates to provide a consistent sample level • Ensuring the calibration table is optimized to the consumables and type of sample • Reducing dimensional variation in labware
  • 15. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA Accuracy dependent on the type of consumable used • +/- 10 µL in 1.4mL tube • +/- 5 µL in PCR plates • Conical and V-shaped well plates return better accuracy at smaller volumes • Flat bottom well plates may require more volume at the bottom of the well to achieve good accuracy VolumeCheck100 Accuracy Deep well Flat-bottom 10μL 5μL 75μL 1.4mL tube Conical PCR well V-Shaped Volume depicted below are for general examples. Actual volumes dependent on final plate used.
  • 16. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA Main Processing Screen • Load calibration table • Select specific wells to read • Start and stop anytime • Volume data displayed while scanning • Graphical interface of volume detected  Entire plate map  Inspection by row • Output file created at the end of each plate scan VolumeCheck100 Software Features
  • 17. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA Plate Data Creator Utility • Plate maps  enter known volumes to plot • Calibration curve data collected  data plotted on curve • Curve fitting tools  split curve to define upper and lower segments for best data fit VolumeCheck100 Software Calibration Curves
  • 18. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA Distance from the sensor to the sample corresponds to a known volume level  Curve represents data points of known volumes vs. distance measured  Curve fitting tools help to fine-tune data for best resolution VolumeCheck100 Software Calibration Curves
  • 19. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA VolumeCheck100 Example Calibration Curves Sarstedt 2mL vial Micronic 1.4mL vial
  • 20. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA Display Settings Screen  Control the visual representation of volume detected  Up to 10 levels of volume intervals Project Based Workflow  Project file includes error handling settings, display settings, and calibration tables in one project file  Projects files for various consumables and applications  Helpful for labs using multiple types of labware. VolumeCheck100 Software Features
  • 21. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA Print Report Feature • One page includes  Plate map  Scan data  Rack ID  Time and date  Calibration file info • Output to computer’s default printer • Output to PDF file VolumeCheck100 Software Features
  • 22. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA Output File Options  User-definable selection of data to output  Customer determines content and order of data VolumeCheck100 Software Output Files Example Output file  File format - .csv, .txt, or user defined  Customizable
  • 23. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA VolumeCheck100 Common Rack Adapters Shallow Well Rack Adapter Matrix 750µL Rack Adapter 2mL Screw Cap Tube Holder Medium Well Rack Adapter VolumeCheck with Rack Adapter
  • 24. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA VolumeCheck Compare Models Options • Rack adapters • VolumeCheck ActiveX toolkit for custom software integration • Linear bar Code scanner for scanning racks VolumeCheck50 VolumeCheck100 VolumeCheck384 Speed 3 minutes per rack 1 minute per rack 2-3 minutes per rack Labware 24, 48 & 96 well SBS formatted plates and tube racks > Up to 52mm height 24, 48 & 96 well SBS formatted plates and tube racks > Up to 52mm height 24, 48, 96 & 384 well SBS formatted plates and tube racks > Up to 100mm height Best for Labs with low throughput Labs with high throughput Labs with diverse labware Includes: Instrument, Software, Manual, Quick Start Guide, USB Cord Requirements: Windows 8, 7, Vista, 512 MB RAM, One USB Port Dimensions: 10.5” H x 10.3” W x 17.0” D (26cm x 26cm x 43cm) Weight: 27 lbs Electrical: 110-220 VAC 50/60Hz
  • 25. www.biomicrolab.com 925-689-1200 sales@biomicrolab.com 2500-A Dean Lesher Dr, Concord, CA 94520 USA System diagnostics  Drift compensation • Built into the calibration curve  Sensor Calibration Distance • Checks before each scan  BioMicroLab provides a series of self- run diagnostic tests which can be used to periodically confirm proper operation  IQ OQ PQ available Warranty  One-year factory warranty  Factory based preventative maintenance available  Service agreements available VolumeCheck100 Maintenance / Diagnostic tests
  • 26. 925-689-1200 | sales@biomicrolab.com | www.biomicrolab.com Contact BioMicroLab BioMicroLab has been designing lab automation equipment since 2001 and our team has a 20-year track record in manufacturing material handling products from our Northern California facility. BioMicroLab has installed 100s of automated tube handlers and 1,000s of sample management devices at biotech and pharmaceutical companies, hospitals, universities, genomic research facilities and biobanks worldwide. Online www.biomicrolab.com Email info@biomicrolab.com Tel (925) 689-1200 Fax (925) 689-1263 Mail 2500-A Dean Lesher Drive Concord, CA 94520 USA We are committed to offering reliable, results-oriented and cost-effective solutions to our customers.
  • 27. BioMicroLab, Inc. | 2500-A Dean Lesher Dr. Concord, CA 94520 USA 925-689-1200 | sales@biomicrolab.com | www.biomicrolab.com Thank You We appreciate your consideration of our products and hope we have the opportunity to help you accelerate your workflow.
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