03abstrak Anna Yunita Widyanti 10060310062 Skr 2016

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    PENGARUH DARI KONSENTRASI PENGIKAT PVP TERHADAP KARAKTERISTIK TABLET EKSTRAK AIR DAUN KEJI BELING ( Strobilanthes crispa  (L.) Blume)   ABSTRAK  Anna Yunita Widyanti Email: annaajha@ymail.com Telah dilakukan penelitian mengenai pengaruh dari konsentrasi pengikat PVP terhadap karakteristik tablet ekstrak air daun keji beling ( Strobilanthes crispa  (L.) Blume) dengan metode granulasi kering. Daun keji beling digunakan sebagai zat aktif karna kandungan mineralnya yang dapat digunakan sebagai diuretik. Ekstrak air diperoleh dengan metoda infusa yang dikeringkan dengan  freeze dryer  . Ekstrak diformulasikan menjadi tablet dengan menvariasikan pengikat PVP pada konsentrasi 1, 3, dan 5%. Pengujian yang dilakukan meliputi evaluasi granul yang meliputi kecepatan alir, kelembaban, bobot jenis dan granulometri, kemudian granul tersebut ditabletasi dan dilakukan evaluasi tablet selama dua minggu pada suhu ruangan yang meliputi uji organoleptis, keseragaman ukuran, keseragaman bobot, kekerasan, friksibilitas, friabilitas dan uji waktu hancur. Berdasarkan hasil evaluasi, disimpulkan bahwa penambahan pengikat PVP dengan berbagai konsentrasi tidak berpengaruh terhadap karakteristik sediaan tablet ekstrak cair daun keji beling. Dari ketiga formula yang dibuat, formula 3 dengan pemakaian konsentrasi PVP 5% menunjukan karakteristik yang lebih baik dari pada formula 1 dan formula 2, tetapi pada dasarnya ketiga formula kurang memenuhi persyaratan karakteristik tablet yang baik. Kata kunci : daun keji beling, tablet, PVP, granulasi kering, infusa,  freeze dryer    repository.unisba.ac.id    THE EFFECT OF PVP BINDER CONCENTRATION ON THE CHARACTERISTICS OF KEJI BELING LEAVES AQUEOUS EXTRACT TABLET ( Strobilanthes crispa  (L.) Blume) ABSTRACT  Anna Yunita Widyanti Email: annaajha@ymail.com Had been conducted research on the effect of PVP concentration as a binder to the characteristics of keji beling leaves aqueous extract tablet ( Strobilanthes crispa  (L.) Blume) by dry granulation method. Keji beling leaves is used as an active ingredient because its mineral content that can be used as a diuretic. Keji beling leaves aqueous extract obtained by the infusion method and dried by  freeze dryer  . The extract was formulated into a tablet with various binder polivinilpirolidon (PVP) concentration of 1, 3, and 5%. Testing was conducted on the evaluation of granules consist of flow rate, humidity, mass density and granulometri test, then the granules were compressed and the tablets were evaluated for two weeks at room temperature consist of organoleptic, content uniformity, weight variation, hardness, frictibility, friability and disintegration time test. Based on the evaluation, it could be concluded the addition of PVP binder with various concentrations did not effect the characteristics of keji beling leaves aqueous extract tablet. From the three formulas that were made, formula 3 with a concentration of 5% PVP showed better characteristics than the formula 1 and 2, but basically all three formulas did not meet the requirements of the characteristics for a good tablet. Keywords : keji beling leaves, tablet, PVP, dry granulation method, infusion,  freeze dryer repository.unisba.ac.id
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